From Science Daily…
New research from Texas Biomedical Research Institute suggests that long-term use of very small amounts of THC may reduce inflammation and ease several harmful effects linked to HIV and antiretroviral therapy (ART).
THC, short for tetrahydrocannabinol, is the primary active compound found in cannabis. In this preclinical research, scientists used extremely low doses that did not cause noticeable nervous system effects such as euphoria or a “high.”
Researchers observed several potential benefits, including higher levels of serotonin and reductions in inflammation, cholesterol, and toxic secondary bile acids. One of the most striking findings was that levels of ART medications in the bloodstream were lower, even though viral suppression remained intact. Because ART drugs can strain the liver over time, this reduction may be especially meaningful. The study was conducted in animal models that closely reflect people living with HIV who are receiving ART, and the results were recently published in Science Advances.